بررسی خواص ضدالتهابی بیس فسفونات ها (مقاله مروری)

Authors

حاتمیان , بیژن

شیاری , رضا

فریور , شیرین

ناصحی , محمدمهدی

Abstract:

Bisphosphonates are currently used in metabolic disorder of bone however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in-vivo. Bisphosphonates were divided in two classes regarding the structure and mechanism, including amino and non-amino bisphosphonates. The effect of bisphosphonates on cytokine related to in-vitro was complex and related to type and dose of bisphosphonates, examination of cell type and cell culture evaluation system. However, amino bisphosphonates activated inflammatory cytokine regarding to in-vivo and chronic usage of this agent, can stop the production of these cytokines. Present study surveyed the anti -inflammatory and immune modulatory effect of bisphosphonates and clinical trial, along with recent knowledge about potential mechanism of this component.

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Journal title

مجله دانشگاه علوم پزشکی مازندران

volume 19 issue 69

pages 79- 87

publication date 2009-03

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